Mustafa Raza & other: 2008

Monday 8 September 2008

Targanta Therapeutics Announces Positive Top-Line Results From Oritavancin Phase 2 SIMPLIFI Trial - Antibiotic Targeting Gram-positive Organisms

�Targanta Therapeutics Corporation (Nasdaq: TARG) announced positive top-line results from a Phase 2 clinical trial investigating the efficacy and safety of oritavancin at Single or Infrequent Doses for the Treatment of Complicated Skin and Skin Structure Infections (cSSSI), or SIMPLIFI. Oritavancin is Targanta's lead antibiotic prospect targeting gram-positive organisms, including methicillin-resistant Staphylococcus aureus, or MRSA. Oritavancin, administered in a single or in an infrequent dosing regime, demonstrated like efficacy and safety to a three-to-seven day line of oritavancin therapy, as administered in two antecedently conducted Phase 3 clinical trials for the treatment of cSSSI. Each of these Phase 3 clinical trials met their primary endpoint.

These top-line efficacy results from SIMPLIFI ar consistent with Targanta's antecedently published preclinical studies. The SIMPLIFI trial run was intentional based on oritavancin's unique pharmacokinetic profile and demonstrated concentration-dependent bactericidal activity.

Mark Leuchtenberger, President and CEO of Targanta, commented, "We believe the potential to cure cSSSI with simply a single or infrequent dosing regimen could make oritavancin the go-to drug of pick among physicians who ar seeking an effective and convenient weapon for their antibiotic armamentarium, and thereby lead to a dislodge in the treatment image for gram-positive infections. With the SIMPLIFI results in hand, we will set about to purpose a bigger confirmatory tribulation that could demonstrate oritavancin's potential as the market's first good single or infrequent endovenous (IV) treatment of cSSSI caused by gram-positive bacterium."

Results of the Phase 2 SIMPLIFI trial volition be victimized to designing a Phase 3 written report to appraise the benefits and risks of a single-dose regime for the treatment of cSSSI. Targanta expects full data from SIMPLIFI volition be presented prior to the final stage of the year.

About SIMPLIFI

The Phase 2 SIMPLIFI test was an international, multi-center, randomized, double blind, controlled subject area of some 300 patients with cSSSI, including MRSA. SIMPLIFI measured clinical response to oritavancin (either cure or improvement versus bankruptcy) at the first followup visit (Test of Cure) in clinically evaluable patients as its primary terminus. The survey examined the safety of oritavancin in all intent-to-treat patients as its junior-grade endpoint.

Additional details around the SIMPLIFI trial design can be found in a press release dated May 20, 2008, "Targanta Completes Enrollment in Phase 2 Oritavancin Infrequent Dosing Study," set up on the Investor Relations section of Targanta's site at world Wide Web.targanta.com/investors/newsrelease.html.

About Oritavancin

Oritavancin is a novel man-made lipoglycopeptide antibiotic drug candidate with potent bactericidal (killing) activity against a broad spectrum of gram-positive bacteria. In its intravenous (IV) formulation, the production candidate has been tried and true in over 2,four hundred individuals and has realised two Phase 3 studies for the treatment of complicated skin and skin structure infections (cSSSI) in which the primary endpoints were met. Targanta submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) in February 2008 seeking to commercialize oritavancin for the treatment of cSSSI; the FDA recognised the NDA submission for standard review, establishing an action day of the month of December 8, 2008. Targanta's Marketing Authorization Application (MAA) for oritavancin was accepted for review by the European Medicines Agency (EMEA) in June 2008. Targanta is also development an oral version of oritavancin for the possible treatment of Clostridium difficile-related conditions.

About Targanta Therapeutics

Targanta Therapeutics Corporation (Nasdaq: TARG) is a biopharmaceutical company focussed on development and commercializing innovative antibiotics to do by serious infections in the hospital and other institutional settings. The Company's word of mouth includes an intravenous version of oritavancin, a semisynthetic lipoglycopeptide antibiotic currently awaiting U.S. and EU regulatory approval, and, a computer programme to develop an oral version of oritavancin for the handling of Clostridium difficile. The Company has operations in Cambridge, MA, Indianapolis, IN, and Montreal, Qu�bec, Canada. For more than information on Targanta, visit http://www.targanta.com.

Safe Harbor Statement

This press outlet contains "forward-looking statements" that are made pursuant to the safe harbor viands of the Private Securities Litigation Reform Act of 1995. These are statements that ar predictive in nature, that depend upon or refer to future events or conditions or that include words such as "potential," "may," "will," "expects," "projects," "anticipates," "estimates," "believes," "intends," "plans," "should," "seeks," "hope" and alike expressions. Such statements include, but are not limited to the potential to cure cSSSI with exactly a undivided or infrequent dosing regimen of oritavancin; oritavancin seemly the antibiotic drug of choice among physicians; and oritavancin's potency as the market's number one effective, single or infrequent intravenous (IV) infusion for treatment of cSSSI caused by gram-positive bacteria. Forward-looking statements involve known and unknown risks and uncertainties that crataegus oxycantha cause literal future results to differ materially from those sticking or contemplated in the forward-looking statements. Forward-looking statements may be significantly wedged by certain risks and uncertainties described in Targanta's filings with the Securities and Exchange Commission. The risks and uncertainties referred to higher up include, just are not limited to, delays in obtaining or a failure to obtain regulatory blessing for Targanta's product candidates; unfavorable clinical trial results; Targanta's potentiality inability to initiate and complete presymptomatic studies and clinical trials for its product candidates; the possibility that results of preclinical studies are not necessarily predictive of clinical trial results; and those other risk factors that are described more fully in the Company's filings with the Securities and Exchange Commission. Targanta does non undertake any obligation to update whatsoever of these forward-looking statements to reverberate a variety in its views or events or circumstances that occur after the date of this release.

Targanta Therapeutics

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Tuesday 19 August 2008

Pamela Anderson dating a royal - report

Pamela Anderson dating a royal - report - New Zealandhttp://www.stuff.co.nz/http://www.stuff.co.nz/http://www.stuff.co.nz/http://www.stuff.co.nz/http://www.stuff.co.nz/'s source for entertainment news, gossip & music, motion-picture show & book reviews on Stuff.co.nz

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Top 10 TV picks: August 12-18

The best films on the box: August 12-18

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Saturday 9 August 2008

Jolie agrees deal for photos of twins

Angelina Jolie and Brad Pitt have agreed a multi-million euro deal for the first photos of their twins, Knox and Vivienne.

The deal is with Hello! cartridge holder and the issue volition be on sale on Monday 4 August.

The Press Association quotes an unidentified magazine source as locution: "This is one of the publishing sensations of the decade - Brad and Angelina are the dream duo of the glossy cartridge clip world and we anticipate to triple our circulation because of the public's fascination and interest in the duo and their children."

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Tuesday 1 July 2008

Sinner

Artist: Sinner

   Genre(s):
Metal
   Metal: Heavy

Discography:

Mask Of Sanity

Year: 2007
Tracks: 12

There Will Be Execution

Year: 2003
Tracks: 12

The End Of Sanctuary

Year: 2000
Tracks: 12

The Second Decade

Year: 1999
Tracks: 15

The Nature Of Evil

Year: 1998
Tracks: 13

Judgement Day

Year: 1997
Tracks: 11

Comin' Out Fighting

Year: 1986
Tracks: 10

Danger Zone

Year: 1984
Tracks: 11

Fast Decision

Year: 1983
Tracks: 10

Wild'n'evil

Year: 1982
Tracks: 11

Led by vocalist Mats Sinner, Sinner was a German metal ring reminiscent of countrymen like the Scorpions and Accept. Their first American spill, Fast Decision, appeared in 1983; it was followed a year later by Danger Zone, widely considered their deuce best records. Several more albums followed in front the band called it quits in 1988; later on Sinner and guitar player Tom Naumann played together with Helloween's Kai Hansen in a dance band called Primal Fear, which released a self-titled debut in 1998, the erstwhile deuce resurrected Sinner for a new album. Dubbed The Nature of Evil, the disk was released later that year. The End of Sanctuary followed in 2000.

Monday 23 June 2008

West Wing star joins Desperate Housewives

After a lengthy search, the actor who will play Katherine Mayfair's (Dana Delany) ex-husband in 'Desperate Housewives' has been found.
TV Guide reports that former 'West Wing' star Gary Cole has signed on to play the character.
Cole's first episode will be screened on US TV on 20 April.
The actor's other credits include 'Midnight Caller' and 'Office Space'.
For more on 'Desperate Housewives', read our blog here.

Wednesday 18 June 2008

Reality TV rejects set for Eurovision?

A number of former reality television stars are set to compete for the chance to represent the UK at this year's Eurovision Song Contest.
Among those vying for the chance to perform at the event in Belgrade in May are former 'X Factor' star Andy Abraham, 'Any Dream Will Do' star Rob McVeigh and 'How Do You Solve a Problem Like Maria?' contestant Simona Armstrong.
They will face competition from former 'EastEnders' star Michelle Gayle, pop duo Loveshy (made up of contestants from 'Popstars: The Rivals') and girl group The Revelations.
The six acts will take part in the 'Eurovision - Your Decision' programme next month, with the winner becoming the UK's official entry for the Eurovision.
BBC's Eurovision host Terry Wogan said: "A turkey is one of the contenders for this year's Irish entry. For the past few years, we've been picking a turkey for the UK.
"Let's hope that the British public will make the right decision this year and give the UK's entry a fighting chance against the Eastern Bloc in Belgrade in May."
For more on Ireland's Eurovision hopefuls, click here.

Monday 16 June 2008

El Chicano recaptures the magic at the Greek

On Sunday at the Greek Theatre, a reunited El Chicano showed that the band is worthy of renewed attention as one of the most accomplished exponents of the Eastside sound. Led by the white-haired Bobby Espinosa -- who was perched behind his beloved Hammond B-3 organ, draped for the occasion in a colorful Mexican serape -- El Chicano performed on the second of a two-night concert series called Latin Legends Live!, now in its seventh year at the Greek.

The weekend lineup included other warhorses of the Chicano nostalgia circuit, including headliners War and Tierra, along with Thee Midniters and Malo with Jorge Santana.

Tierra's lively party set featured brothers Rudy and Steve Salas, who once played with El Chicano and who had their own big reunion at the Conga Room in 2002. The band's outstanding current vocalist, Billy Mondragon, could have won the night's "Chicano Idol" competition for his soulfulness, power and pure falsettos.

Sunday's afternoon gloom might have slightly dampened the turnout. But the audience of mostly middle-aged Mexican Americans, many with the trademark goatees and tattoos of veteranos, filled the amphitheater with celebratory enthusiasm for the old-school music that served as a soundtrack for their youth.

The night offered a welcome reminder of how many excellent musicians emerged from the California Chicano community after the success of Carlos Santana and his trademark pop concoction, Latin rock. Unfortunately, nostalgia now fills a void because Chicano bands, with the exception of Los Lobos, have struggled to recapture the 1970s level of popularity.

While not strictly a Chicano band, War (Eric Burden's ex-backup group) fits the Santana mold with its multicultural makeup and its fusion of rock, R&B, salsa and jazz, exemplified by its 1975 Top 10 hit "Low Rider."

El Chicano's "Viva Tirado" was one of those pop music flukes, a jazzy instrumental written by pianist Gerald Wilson, an African American who happened to love bullfighting. El Chicano's 1970 cover version became a Top 40 hit, though it was recorded when the group was still known as the V.I.P.s, a moniker changed by a producer after signing a record deal. Overnight and unwittingly, the band was turned into a symbol for the tumultuous political movement that also called itself Chicano.

Espinosa has kept the group going with various lineups, but this is the first time in more than 20 years that almost all the early members were back on stage together. They include Freddie Sanchez (bass), Jerry Salas (vocals and guitar), Rudy Regalado (timbales), John De Luna (drums) and Mickey Lespron (guitar).

The band's veteran lead singer Ersi Arvizu was warmly received for a guest vocal on her signature bolero, "Sabor A Mi." She did the number like a diva and exited with a pitch: "Don't forget to buy my CD. Believe me, it sounds just like El Chicano." Well, not exactly. The work has little to do with Latin rock and stays truer to the bolero's romantic essence.

Lespron is the only band member who plays on Arvizu's album, "Friend for Life." On Sunday, he lit up the stage with thrilling guitar solos, switching to a vintage 1962 Gibson for "Viva Tirado," the guitar he used on the original recording.

"It felt great, man," said Lespron backstage after the show. "The magic's still there."

agustin.gurza@latimes.com

Duffy tops Mojo honours list

Duffy's "timeless" smash hit single Mercy was named Song Of The Year
tonight in the Mojo Honours List 2008.

Nominated in three categories, more than any other artist, Duffy joined fellow
Honours List winners Led Zeppelin, Paul Weller, the Sex Pistols, Genesis,
Neil Diamond and The Specials.

Duffy was beaten as Best Breakthrough Act by Arctic Monkeys frontman Alex
Turner's side project The Last Shadow Puppets.

The Welsh singer-songwriter also lost out on the Best Album Award to Nick Cave
& The Bad Seeds for their offering Dig!!! Lazarus Dig!!!

The event was hosted by Mojo magazine's editor-in-chief Phil Alexander at The
Brewery in east London.

Mr Alexander said of Mercy: "It's a timeless song which is exactly why Mojo
readers voted for it.

"It could really have come from any period in time over the last 50 years.

"At the start of the year she was one of the artists in our Eight For 08
feature but we didn't expect her to sell a million albums in the UK in six
months!"

The guest-list at the event included Dave Grohl, Kate Nash, Al Murray, David
Arnold, Phill Jupitus, Georgie Fame and Graham Coxon.

The ceremony, dedicated to celebrating modern music, consisted of key awards
which were voted for by readers of the monthly music bible Mojo magazine and
users of its website www.mojo4music.com.

Spanning more than three decades and hailed as one of Britain's finest heavy
metal bands, Motorhead were honoured with the Mojo Hero award.

Mr Alexander said: "This category recognises an act or artist that we at Mojo
truly admire and love, and whose achievements we feel have been grossly
overlooked.

"Lemmy and Motorhead have proved time and again what a unique force they are.

"They have remained true to the basic spirit of rock n' roll and continue to
astound us with the sheer volume of their performances.

"They've influenced everyone from Metallica to Primal Scream.

"The reason: well, there's simply no better way to go deaf than by listening
to Motorhead."

The Sex Pistols were presented with the Mojo Icon Award.

Mr Alexander said: "As punk's standard-bearers, the Sex Pistols truly
re-defined modern music in the space of one solitary album. Who else has
managed that?

"They also influenced every aspect of popular culture - from fashion to the
media, film and literature and on to the music industry itself.

"They remain totems for rebellion in a manner that is totally unique and which
we are proud to salute with this award."

Having re-united for a blistering show at the O2 Arena at the end of 2007 Led
Zeppelin took home the Best Live Act Award.

The Classic Songwriter Award went to Diamond, presented by fellow musician
Richard Hawley.

Two-tone ska band the Specials were selected for the Mojo Hall Of Fame,
joining previous winners such as Sir Elton John and The Doors.

Mr Alexander said: "Everyone wishes that the Specials were still around now.

"Not only was their music terrific but they stood for something in terms of
what they had to say."

Genesis were awarded the Mojo Lifetime Achievement Award for an outstanding
career that positions them as one of the top 30 highest-selling recording
artists of all time with about 150 million albums sold worldwide.

The Mojo Special Award went to Grammy award-winning soprano singer Judy
Collins.

Another Grammy award winner, New Orleans-based blues and soul singer Irma
Thomas, flew into the UK to collect the Mojo Legend Award.

Alternative rock band My Bloody Valentine won the Mojo Classic Album Award for
their critically acclaimed work Loveless.

John Fogerty received the Mojo Inspiration Award for his contribution to rock
music and "Modfather" Weller received the Outstanding Contribution To Music
Award.

Meanwhile ska and roots reggae master Toots Hibbert took home the Mojo Roots
Award which was presented by Jazzie B.

Other winners included folk legend John Martyn, who scooped the Mojo Les Paul
Award and the Fall's frontman Mark E Smith who received the Mojo Maverick
Award.

The Mojo Vision Award went to Julien Temple for his documentary The Future Is
Unwritten about the life of Clash frontman Joe Strummer.

Juno Original Soundtrack won the Mojo Compilation Of The Year Award and the
Mojo Catalogue Release Of The Year went to Pillows & Prayers, Cherry Red
Records 1981 - 1984.

Here are the winners on the Mojo Honours List 2008:

Song of the Year Award: Mercy by Duffy

Best Breakthrough Act: The Last Shadow Puppets

Best Album Award: Dig!!! Lazarus Dig!!! by Nick Cave & The Bad Seeds

Hero Award: Motorhead

Icon Award: the Sex Pistols

Best Live Act Award: Led Zeppelin

Classic Songwriter Award: Neil Diamond

Hall of Fame: The Specials

Lifetime Achievement Award: Genesis

Special Award: Judy Collins

Legend Award: Irma Thomas

Classic Album Award: Loveless by My Bloody Valentine

Inspiration Award: John Fogerty

Outstanding Contribution to Music Award: Paul Weller

Roots Award: Toots Hibbert

Les Paul Award: John Martyn

Maverick Award: Mark E Smith

Vision Award: Julien Temple for The Future is Unwritten

Compilation of the Year Award: Juno Original Soundtrack

Catalogue Release of the Year: Pillows & Prayers Cherry Red Records 1981-1984

See Also

The 'American' revolution

3. David Cook, “The Time of My Life”
5. Jordin Sparks with Chris Brown, “No Air”
15. David Cook, “Dream Big”
22. David Cook, “I Still Haven’t Found What I’m Looking For”
19. Carrie Underwood, “Last Name”
28. David Cook, “The World I Know”
36. David Archuleta, “Imagine”
42. David Cook, “I Don’t Want to Miss a Thing”
45. Daughtry, “Feels Like Tonight”
47. David Cook, “Billie Jean”
58. David Archuleta, “Don’t Let the Sun Go Down On Me”
60. David Archuleta, “In This Moment”
67. David Cook, “Always Be My Baby”
73. David Cook, “Hello”
77. David Cook, “The Music of the Night”
92. David Cook, “Eleanor Rigby”
99. David Cook, “I’m Alive”

Metal Church

Artist: Metal Church

   Genre(s):
Metal: Heavy
   Metal
   Rock

Discography:

A Light In The Dark

Year: 2006
Tracks: 11

The Weight Of The World

Year: 2004
Tracks: 10

Masterpeace

Year: 1999
Tracks: 11

Live

Year: 1998
Tracks: 10

Hanging In The Balance

Year: 1993
Tracks: 12

The Human Factor

Year: 1991
Tracks: 10

Blessing In Disguise

Year: 1989
Tracks: 9

The Dark

Year: 1986
Tracks: 10

Metal Church

Year: 1985
Tracks: 9

Four Hymns '84 (Demo)

Year: 1984
Tracks: 4

Formed Seattle in 1982, Metal Church consisted of vocalizer David Wayne, guitarists Kurdt Vanderhoof and Craig Wells, bassist Duke Erickson, and drummer Kirk Arrington. Their 1985 self-titled debut album, recorded when the thrash/speed metal genre was tranquil evolving, made a immense splosh on the scene, as did its similar reexamination, The Dark. However, the band very hit its tread when Wayne left and was replaced by Mike Howe on 1989's Blessing In Disguise; Vanderhoof left after the album due to his disapproval of touring and was replaced by Metallica guitar technical school John Marshall. Vanderhoof remained the group's designated composer on 1991's The Human Factor, possibly the band's most socially conscious record album. However, the second Advent of alternative stone and problems with their record label contributed to a loss of direction on 1993's Wall hanging in the Balance, and Metal Church complete up disbanding. In 1999, the group's original lineup -- Wayne, Vanderhoof, Wells, Erickson, and Arrington -- reunited and released the album Masterpeace. Alive appeared early the following yr.

Mau Mau

Artist: Mau Mau

   Genre(s):
Jazz

Discography:

Dea

Year: 2007
Tracks: 11

Pamela Anderson - Pamela Anderson And Ex-husband Tommy Lee Dating

Starsailor cover U2, The Stone Roses and Gorillaz at Isle Of Wight

Starsailor covered U2, The Stone Roses and Gorillaz during an afternoon slot on the main stage at the Isle Of Wight Festival this afternoon (June 15), as well as playing a slew of new songs.

Taking the stage at 5pm (BST) on the final day of the festival, the band were playing on the third day of rain-less sunny weather at the island bash.

After opening with 'Alcoholic' and 'Poor Misguided Fool', singer/guitarist James Walsh introduced a new song, 'Tell Me It's Not Over'. "It's the first time we've played this at a UK festival," he announced.

The new song showcases a melodic piano riff reminiscent of early Coldplay and a mid-to-fast pace, and earned a loud declaration of love from the front row. "We love you to!" shouted Walsh in response.

Later in the set Walsh dedicated another new song, 'Boy In Waiting', to Hank Williams. "It's a bit of a country song," he said.

Following 'In The Crossfire' Walsh played an acoustic tribute to The Stone Roses. He played a section of their hit 'She Bangs The Drums' before leading into 'All The Plans We Make', another song destined for the band's forthcoming new album, due later this year.

Starsailor made another band tribute at the death of the following 'Four To The Floor'. They extended the song, with Walsh singing, "It's dare!", a reference to 'Dare' by Gorillaz.

The final tribute of the set came during set closer 'Good Souls', during which the band played a section of U2's 'Where The Streets Have No Name' as an interlude.

Starsailor played:

'Alcoholic'
'Poor Misguided Fool'
'Tell Me It's Not Over'
'Fever'
'Boy In Waiting'
'In The Crossfire'
'She Bangs The Drums'
'All The Plans We Make'
'Four To The Floor' (followed by 'Dare' tribute)
'Tie Up My Hands'
'Silence Is Easy'
'Good Souls' (including 'The Streets Have No Name' interlude)